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In a study published in the journal Food and Chemical Toxicology in 2016, researchers investigated whether titanium dioxide exposure led to an increase in colorectal tumor creation in mice by using a colitis associated cancer model. By measuring tumor progression markers, the researchers found that mice given titanium dioxide experienced enhanced tumor formation in the distal colon.  There was also a decrease of cells that act as a protective barrier in the colon. The researchers wrote: “These results suggest that E171 could worsen pre-existent intestinal diseases.”

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The synergy between talc and titanium dioxide is particularly evident in the manufacturing of plastics. When these two minerals are added to plastic formulations, they can improve the strength, impact resistance, and heat stability of the final product. This is because talc acts as a filler, filling the spaces between polymer molecules, while titanium dioxide enhances the polymer's molecular structure, making it more resistant to external stresses.

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